The short answer

The federal report is about the drugs, not the person. If there was a theft or significant loss, the DEA must be told in writing within one business day of discovery, whether or not you know who took them. Reports about the employee, to a licensing board or the police, are set by state law and by the board that licensed them, and they differ from state to state and between professions.

Who may need to be told

WhoWhenSet by
DEA Field Division OfficeTheft or significant loss: in writing “within one business day of discovery”, then a complete DEA Form 106 “within 45 days after discovery”.21 CFR 1301.76(b)
Pharmacy director and CEO (hospitals)“Abuses and losses of controlled substances must be reported, in accordance with applicable Federal and State laws, to the individual responsible for the pharmaceutical service, and to the chief executive officer, as appropriate.”42 CFR 482.25(b)(7)
State board of pharmacyThefts and losses, under the state's own rules and deadline, which can be shorter or broader than DEA's.State pharmacy law. Varies by state.
The employee's licensing boardWhether an employer must report a nurse, pharmacist, technician or physician, and how fast, depends on the state and the profession. In some states it is mandatory; elsewhere it may be left to judgment.State law and that board's rules. Varies by state and profession.
Law enforcementThe federal rules cited here do not require a police report. Whether to make one is a decision for leadership and counsel, under any state rule that applies.Your policy and counsel.
PatientsIf tampering or substitution may have affected care or exposed patients to infection.See patient notification after drug diversion.

Your registration, license and accreditation may each add obligations. Check them for your own facility rather than relying on this table alone.

Do not wait for the investigation to finish

The one-business-day clock runs from discovery of the theft or loss, not from the end of your investigation or the employee's interview. There is no fixed quantity that makes a loss significant. The regulation lists factors to weigh, including the quantity in relation to the type of business, the specific drug, “whether the loss of the controlled substances can be associated with access to those controlled substances by specific individuals”, and any pattern of losses over time (21 CFR 1301.76(b)). If the loss can be tied to one employee, that is itself one of the factors.

The DEA Form 106 guide covers what goes on the form.

Reports from staff, inside the organization

Most concerns start with a colleague. DEA has stated its position that “an employee who has knowledge of drug diversion from his employer by a fellow employee has an obligation to report such information to a responsible security official of the employer”, and that the employer “shall take all reasonable steps to protect the confidentiality of the information and the identity of the employee furnishing information” (21 CFR 1301.91).

That section sits under the heading “Employee Screening—Non-Practitioners”, which covers registrants such as distributors, not hospitals or pharmacies. Do not cite it as a rule that binds a hospital or pharmacy. It is still a sound model for your own policy: tell staff they must report, tell them to whom, and protect the person who does. For the staff-side steps, see how to report drug diversion.

When the employee reports themselves

Some diversion comes to light because the employee discloses a substance use problem. Many states have an alternative-to-discipline or peer assistance program for licensed professionals. Who is eligible, whether a self-report changes what the employer must report, and what the board is told all depend on the state and the profession. Ask the licensing board or the program directly, and check with counsel before telling the employee what will happen. A self-report does not remove the DEA report if drugs were lost.

Keep a record of every report

For each report, keep the date and time it was made, who made it, who received it, what it said, and any reply or reference number. When an inspector or a board asks whether a loss was reported on time, this is the record that answers.

Sources

Read on October 16, 2026. Educational content, not legal advice; check your state's current rules and your licensing boards' rules before relying on a deadline.

Further reading

Reporting the loss

The one-business-day notice and the Form 106.

Investigating the employee

Gathering the evidence and interviewing fairly.

Other topics

Check your reporting and investigation process

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Last reviewed: September 2026 · Content is educational, not legal advice.